Exploring the Health Benefits and Economic Opportunities of the Bioactive Compounds Isolated from Eastern Redcedar in Missouri
Most people would never suspect that a “trash tree,” one with little economic value and often removed by farmers due to its ability to destroy farmland, could be the key to fighting a deadly bacterium.
Now, a Mizzou Advantage-funded researcher has found an antibiotic in the Eastern Red Cedar tree that is effective against methicillin-resistant Staphylococcus aureus (MRSA), a “superbug” that is resistant to most medications.
MRSA is an evolving bacterium that is resistant to most medications. For most people, the infection is isolated to the skin. However, it can spread to vital organs causing toxic shock syndrome and pneumonia, especially in people with weakened immune systems. The incidence of disease caused by MRSA bacteria is increasing worldwide.
While the Eastern Red Cedar has few commercial uses, it is present in the U.S. in large numbers and its range extends from Kansas to the eastern United States. An estimated 500 million trees grow in Missouri. Lin began his investigation by building on existing research showing the anti-bacterial potential of chemical compounds derived from the tree.
Mizzou Advantage awarded a seed grant to Chung-Ho Lin, research assistant professor in the MU Center for Agroforestry at the College of Agriculture, Food and Natural Resources, to advance studies in this emerging area.
“I wanted to find a use for a tree species that is considered a nuisance,” said Lin. “This discovery could help people fight the bacteria as well as give farmers another cash crop.”
Lin, George Stewart, professor and department chair of Pathobiology in the College of Veterinary Medicine, and Brian Thompson, postdoctoral fellow in the Bond Life Sciences Center, identified, isolated and tested 17 bioactive compounds and has plans to analyze more compounds. Scientists found that a relatively small concentration of a chemical compound found in the Eastern Red Cedar– 5 micrograms per milliliter – was effective against MRSA. The team tested the compound’s effectiveness against many versions of MRSA in a test tube with promising initial results.
“We found this chemical from the cedar needles, an abundant and renewable resource that can be collected annually,” co-researcher Brian Thompson said. “Because the compound is in the needles, we don’t have to cut down the trees.”
In addition to its potential use in fighting MRSA, researchers found that some chemical compounds in the tree are able to fight and kill skin cancer cells present in mice. It might also be effective as a topical acne treatment. Stewart said the compounds are years away from commercial use, as they must go through clinical trials.
The team’s research was presented recently at the International Conference on Gram-Positive Pathogens at the Great Plains Infectious Disease Meeting in 2011. The research has also been presented at the 12 North American Agroforestry Conference in Athens, Georgia.
One Health/One Medicine