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Cholesterol-Reducing Drug May Reduce Exercise Benefits for Obese Adults

May 17, 2013


University of Missouri-Columbia researcher John Thyfault and his colleagues have found that statins, prescribed for high cholestorol and heart disease prevention, may actually reduce the benefits of exercise in obese patients. Thyfault is an associate professor in the MU Department of Nutrition and Exercise Physiology. This study is related to the One Health/One Medicine initiative of Mizzou Advantage.


Story by:  MU News Bureau

Statins, the most widely prescribed drugs worldwide, are often suggested to lower cholesterol and prevent heart disease in individuals with obesity, diabetes and metabolic syndrome, which is a combination of medical disorders including excess body fat and/or high levels of blood pressure, blood sugar and/or cholesterol. However, University of Missouri researchers found that simvastatin, a generic type of statin previously sold under the brand name “Zocor,” hindered the positive effects of exercise for obese and overweight adults.

“Fitness has proven to be the most significant predictor of longevity and health because it protects people from a variety of chronic diseases,” said John Thyfault, an associate professor of nutrition and exercise physiology at MU. “Daily physical activity is needed to maintain or improve fitness, and thus improve health outcomes. However, if patients start exercising and taking statins at the same time, it seems that statins block the ability of exercise to improve their fitness levels.” See more…