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Collaborative Success Stories: Quali-tea Research

green tea

University of Missouri researchers have discovered that a compound found in green tea, combined with exercise, could reverse the effects of Alzheimer’s disease.

In Alzheimer’s patients, an excess of a peptide called A-beta causes harmful plaques in the brain—leading to memory loss, agitation and lack of concern for one’s domestic surroundings. Based on previous research conducted at Mizzou, a team of researchers led by Dr. Todd Schachtman and MU student Jennifer Walker used exercise and a green tea extract called EGCG to treat mice known to have plaque deposits. Prior to treatment, the mice had trouble completing a maze test and created poorly-formed nests due to apathy about their habitat.

After receiving EGCG in their drinking water and using exercise wheels, the mice built better nests, and their maze testing improved as well. The team analyzed the brain tissues and confirmed a decrease in A-beta levels.

University scientists are continuing to investigate EGCG and other botanicals. Their efforts could lead to advancements in the treatment and prevention of Alzheimer’s disease in humans.

Dr. Todd Schachtman is a professor of psychological sciences in the College of Arts and Science.

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Related Initiative(s):
Food for the Future, One Health/One Medicine,